The law of depravity is a lot like gravity it always brings us down, down, DOWN!
Arnold Brevick

As the salt flavors every drop in the Atlantic, so does sin affect every atom of our nature. It is so sadly there, so abundantly there, that if you cannot detect it, you are deceived.
C.H. Spurgeon

“He instructed him.” How patiently God bears with our dullness! How graciously He repeats “line upon line and precept upon precept” (Is. 28:10)! Yet slow as we are, He perseveres with us, for He has promised to perfect that which concerns us (Ps. 138:8). Has He “instructed” you, my reader? Has He taught you the total depravity of man and the utter inability of the sinner to deliver himself? Has He taught you the humbling truth “Ye must be born again,” and that regeneration is solely the work of God, man having no part or hand in it (Jn. 1:13)? Has He revealed to you the infinite value and sufficiency of the atoning sacrifice of Christ whose blood cleanses “FROM ALL SIN?” Then what cause you have to be thankful for such Divine instruction.
A.W. Pink

The effect of total depravity and inability* on the will* of man as the result of the fall.* The disposition of man’s will being now firmly fixed on self, he is incapable of originating a new godly disposition. He is incapable of spiritual good, dead in trespasses and sins, and walking “according to the prince of the power of the air, the spirit that now worketh in the children of disobedience” (Ephesians 2:2).
Alan Cairns
Dictionary of Theological Terms

21 I find then a law, that evil is present with me, the one who wills to do good. 22 For I delight in the law of God according to the inward man. 23 But I see another law in my members, warring against the law of my mind, and bringing me into captivity to the law of sin which is in my members. 24 O wretched man that I am! Who will deliver me from this body of death? (Rom 7:21-24 NKJ)